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Research > Comparative Effectiveness Study on Major Depression
Datasets > Comparative Effectiveness Study on Major Depression

Comparative Effectiveness Study on Major Depression

The second DARTNet project, designed to illustrate the ability to scale up the advanced informatics infrastructure. Focused upon the certification of DARTNet for depression studies, the development of CDRs to assess the comparative effectiveness of anti-depressants, and to test the ability of DARTNet to collect patient reported data on a large scale via the PHQ2/PHQ9. Aim was to conduct an observational comparative effectiveness and safety study of different therapies for major depression in three phases.

The development of CDS support tools for practice tor managing anti-depressants, and the incorporation of PHQ data into the EHR framework for linking to other EHR data. The study was the first attempt to link EHR data, patient reported data, and claims-based data.

Publications and Results

AHRQ's summary of the project:

Rates of 5 Common Antidepressant Side Effects Among New Adult and Adolescent Case of Depression: A Retrospective US Claims Study.
Anderson HS, Pace, WD, Libby AM, West DR, Valuck RJ.
Clinical Therapeutics. 2012; 34(1): 113-123.

Enhancing Electronic Health Record Measurement of Depression Severity and Suicide Ideation: A Distributed Ambulatory Research in Therapeutics Network (DARTNet) Study.
Valuck RJ, Anderson HO, Libby AM, Brandt E, Bryan C, Allen RR, Staton EW, West DR, Pace WD.
J Am Board Fam Med. 2012 Sep;25(5):582-93.
Abstract | Full Text

Dataset Description

Type of Patients Included N Data Elements
Patients with a diagnosis of depression OR a completed PHQ-9 59862
  • AST
  • Gender
  • Current smoking status
  • Height and Weight/BMI
  • Total physician visits
  • Hepatitis A antibodies (IgG and IgM)
  • Hepatitis B markers
  • Hep B antibodies
  • Hepatitis B viral markers
  • Hepatitis C Antibodies
  • Hepatitis C viral RNA qualitative and quantitative tests
  • Age
  • Hematocrit
  • Episode Dating Data
  • ALT
  • Procedures
  • Prescribed and filled medications
  • Medication Allergies
  • All diagnosis Active
  • All diagnosis inactive
  • Blood pressure
  • Family History of Depression, suicidality or other mental disorders
  • PHQ 2 Score
  • PHQ 9 Score
  • Hemoglobin