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Toolkit for Developing and Conducting Multisite Clinical Trials in Practice Based Research Networks

Interested in conducting a clinical trial in a primary care practice based research network (PBRN)? PBRNs are ideal settings for clinical trials, especially pragmatic clinical trials. This Toolkit was created to help researchers interested in conducting clinical trials in a PBRN setting to answer questions related to:

  • Clinical effectiveness Is a treatment beneficial?
  • Comparative effectiveness Are two treatments equally beneficial? and
  • Safety Are there harms to treatment(s)?

The following links will guide you through the toolkit.

  1. Introduction and Executive Summary
  2. Frequently Asked Questions about Project Management of a Clinical Trial in a PBRN
  3. Frequently Asked Questions about Budgeting a Multisite Clinical Trial in a PBRN
  4. Frequently Asked Questions about Recruiting, Engaging, and Maintaining Practices for a Clinical Trial in a PBRN
  5. Frequently Asked Questions about Communications when Collaborating on a Clinical Trial with a PBRN
  6. Glossary of Terms for PBRN Research Project Teams
  7. Examples and Templates for Developing and Conducting a Clinical Trial in a PBRN
  8. Acknowledgements
  9. PBRN Resource links


This toolkit was developed in collaboration with the DARTNet Institute Research Steering Committee and the Clinical Translational Science Award (CTSA) Practice Based Research Network Workgroup of the Community Engagement Key Function Committee. Please see the acknowledgements section for contributors to this toolkit.


Suggested Citation: Baldwin L-M, Graham D, Schmit K, Dolor RJ, Fox C, Pace W. Toolkit for Developing and Conducting Multi-site Clinical Trials in Practice Based Research Networks. http://www.dartnet.info/ClinicalTrialsBPRNToolkit.htm. Accessed on (insert date).


Next: Introduction and Executive Summary