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The DARTNet Institute is a growing collaboration of many of the premier practice-based research networks in the U.S. DI has conducted studies which cover a wide array of topics, including the comparative effectiveness and safety of oral medications for patients with type 2 diabetes, interventions for treating community acquired MRSA infections, the comparative effectiveness and safety of therapies for major depression, an intervention for reducing the inappropriate use of antibiotics in primary care, the creation of a learning community around cardiovascular disease, and many more.